16-P021 Isolation of NOCE, a novel node and notochord-specific enhancer element from the Noto locus
نویسندگان
چکیده
منابع مشابه
16-P021 Isolation of NOCE, a novel node and notochord-specific enhancer element from the Noto locus
Meckel–Gruber syndrome (MKS) is a rare lethal autosomal recessive disease that is the most common cause of syndromic neural tube defects. There are five causative genes, mapped to six known disease loci, whose products encode proteins involved in formation and function of primary cilia. One of these genes, MKS3 (located on chromosome 8q22.1), is now well-characterized and a number of mutations ...
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15 صفحه اولCharacterization of a notochord-specific enhancer from the Brachyury promoter region of the ascidian, Ciona intestinalis.
We present evidence that the embryo of the ascidian, Ciona intestinalis, is an easily manipulated system for investigating the establishment of basic chordate tissues and organs. Ciona has a small genome, and simple, well-defined embyronic lineages. Here, we examine the regulatory mechanisms underlying the differentiation of the notochord. Particular efforts center on the regulation of a notoch...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.712